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Cardiac Clinical Trials

Centennial Heart is a proven leader in Cardiovascular Research. In 2007, Sarah Cannon Research Institute (SCRI) established our practice as a strategic investigative site for cardiovascular research in Nashville. Now, the program has expanded to 10 strategic sites and more than 125 cardiologists specializing in interventional cardiology, electrophysiology, cardiovascular disease, surgery and structural heart.

At Centennial Heart, our team pioneers clinical trials to constantly innovate solutions and improve patient outcomes.

We are proud to partner with SCRI in transforming cardiovascular therapies and advancing patient care. SCRI sets the standard for effectively managed, reliable clinical research trials.

National Leaders in Cardiac Research

Our nationally recognized cardiovascular research program is designed to provide state of the art, inventive approaches top clinical trial management. At Centennial Heart, our team pioneers clinical trials to constantly innovate solutions and improve patient outcomes.

All of our physicians actively manage multiple studies with SCRI and clinical physicians hold Directorships. Dr. Chris Jones is the Director of Electrophysiology Research. Dr. Jones' cardiac electrophysiology expertise includes evaluation of syncope and palpitations, medical management of arrhythmias, device implantation and follow-up, and catheter ablation of tachy-arrhythmias.

Current Clinical Trials

Condition

Heart failure with reduced EF, LBBB, biventricular dysynchrony

Intervention

CRT- D with Adapt mode randomized on or off

Location
TriStar Centennial
Sponsor
Medtronic Inc.
Principal Investigator
Peter Borek, MD
Research Coordinator
Betsy Galenti, RN
Specialty
Electrophysiology

Condition

Multivessel Coronary Artery Disease

Intervention

Randomization to Coronary Bypass Graft or Fractional Flow Rate guided PCI

Location
TriStar Centennial
Sponsor
St. Jude Medical/Medtronic Inc.
Principal Investigators
R. Paul Myers, MD & Seenu Reddy, MD
Research Coordinator
Hallie Hank, RN
Specialty
Cardiac Intervention & Surgery

Condition

Severe Aortic Valve Stenosis

Intervention

Transcatheter Aortic Valve Replacement with investigational PORTICO valve

Location
TriStar Centennial
Sponsor
St. Jude Medical
Principal Investigator
John Riddick, MD & Seenu Reddy, MD
Research Coordinator
Hallie Hank, RN
Specialty
Cardiac Intervention

Condition

Coronary Artery Disease

Intervention

Use of Aggrastat (current dose or proposed dose) or Integrilin during PCI

Location
TriStar Centennial
Sponsor
Medicure
Principal Investigator
Brian Jefferson, MD
Research Coordinator
James Darby, RN
Specialty
Cardiac Intervention

Condition

Acute heart failure with reduced EF

Intervention

Evaluate the effect of a customized quality improvement program compared with usual care on HF outcomes

Location
TriStar Centennial
Sponsor
Duke Clinical Research Institute
Principal Investigator
Tom McRae, MD
Research Coordinator
Hallie Hank, RN
Specialty
Heart Failure

Condition

Coronary Artery Disease with a high bleeding risk

Intervention

PCI with XIENCE Stent placement and 3 month DAPT therapy

Location
TriStar Centennial
Sponsor
Abbott
Principal Investigator
Paul Myers, MD
Research Coordinator
James Darby, RN
Specialty
Cardiac Intervention

Condition

MI with cardiogenic shock

Intervention

Impella placement and PCI

Location
TriStar Centennial
Sponsor
Henry Ford Hospital
Principal Investigator
Paul Myers, MD
Research Coordinator
Betsy Galenti, RN
Specialty
Cardiac Intervention

Condition

Coronary Artery Disease with severely calcified lesions

Intervention

PCI with orbital atherectomy versus conventional balloon angioplasty

Location
TriStar Centennial
Sponsor
Cardiovascular Systems, Inc.
Principal Investigator
Brian Jefferson, MD
Research Coordinator
James Darby, RN
Specialty
Cardiac Intervention

Condition

Persistent Atrial Fibrillation

Intervention

Conventional PVI ablation or PVI + fibrosis-guided ablation

Location
TriStar Centennial
Sponsor
The University of Utah
Principal Investigator
Chris Jones, MD
Research Coordinator
Betsy Galenti, RN
Specialty
Electrophysiology

Condition

Below the knee peripheral artery disease

Intervention

Below the knee PTA resulting in dissection(s) that are repaired with the Tack Endovascular System

Location
TriStar Centennial
Sponsor
Intact Vascular
Principal Investigator
Bryan Fisher, MD
Research Coordinator
James Darby, RN
Specialty
Peripheral Vascular

Condition

Indicated for cardiac EP mapping and RF ablation

Intervention

Electrophysiology study using the EnSite Precision Cardiac Mapping System

Location
TriStar Centennial
Sponsor
Abbott
Principal Investigator
Gregory Bashian, MD
Research Coordinator
Betsy Galenti, RN
Specialty
Electrophysiology

Condition

Implanted with a Medtronic Evera MRI ICD and history of VT/VF

Intervention

Implantation of a Medtronic tachycardia lead placed in the right ventricle to collect ICD data for a VT/VF prediction algorithm

Location
TriStar Centennial
Sponsor
Medtronic
Principal Investigator
Przemyslaw Borek, MD
Research Coordinator
Betsy Galenti, RN
Specialty
Electrophysiology

Condition

Chronic Total Occlusion

Intervention

PCI of the Chronic Total Occlusion

Location
TriStar Centennial
Sponsor
Minneapolis Heart Institute
Principal Investigator
Brian Jefferson, MD & Taral Patel, MD
Research Coordinator
Drew Quillen, RN
Specialty
Cardiac Intervention

Condition

Asymptomatic, symptomatic, or ruptured aortic aneurysms

Intervention

Aortic aneurysm treatment with the Aptus Heli-FX EndoAnchor System in conjunction with commercially available Endografts

Location
TriStar Centennial
Sponsor
Medtronic
Principal Investigator
Adam Richter, MD
Hallie Hank, RN
Specialty
Cardiac Intervention