Cardiac Clinical Trials
Centennial Heart is a leader in cardiovascular innovation, integrating advanced clinical research with exceptional patient-centered care. As a proud partner of the HCA Healthcare Research Institute, Centennial Heart leverages a robust research infrastructure to deliver cutting-edge therapies to patients. Since 2007, this collaboration has enabled participation in over 200 industry-sponsored trials, enrolling more than 3,000 patients. Through its comprehensive research program, Centennial Heart facilitates the rapid translation of groundbreaking therapies into clinical practice, ensuring patients have access to the latest advancements in cardiology. Centers of excellence dedicated to arrhythmia, heart failure, and structural heart disorders underscore the program’s commitment to comprehensive, multidisciplinary care. By fostering a culture of continuous innovation and collaboration, Centennial Heart not only advances cardiovascular medicine but also delivers personalized, high-quality care that enhances patient outcomes and quality of life.
National Leaders in Cardiac Research
Our nationally recognized cardiovascular research program is designed to provide state of the art, inventive approaches to clinical trial management. At Centennial Heart, our team pioneers clinical trials to constantly innovate solutions and improve patient outcomes.
Condition
Chronic Total Occlusion
Intervention
Registry for PCI of Chronic Total Occlusions
Location
TriStar Centennial
Sponsor
Minneapolis Heart Institute
Principal Investigator
Brian Jefferson, MD
Research Coordinator
Taylor Cook
Specialty
Interventional
ClinicalTrials.gov
Condition
Degenerative mitral regurgitation
Intervention
Compare the Edwards PASCAL System for transcatheter mitral valve repair to the Abbott MitraClip
Location
TriStar Centennial
Sponsor
Edwards
Principal Investigator
John Riddick, MD
Research Coordinator
Abby Bentley
Specialty
Structural
ClinicalTrials.gov
Condition
Heart Failure with functional mitral regurgitation
Intervention
Carillon implant versus control
Location
TriStar Centennial
Sponsor
Cardiac Dimensions
Principal Investigator
Andrew Goodman, MD
Research Coordinator
Abby Bentley
Specialty
Structural
ClinicalTrials.gov
NCT: 03142152
Condition
Moderate-to-severe or severe Mitral Regurgitation
Intervention
Tendyne mitral valve system versus MitraClip system
Location
TriStar Centennial
Sponsor
Abbott
Principal Investigator
Sreekumar Subramanian, MD
Research Coordinator
Lauren Bozarth
Specialty
Structural
ClinicalTrials.gov
Condition
Severe primary mitral regurgitation at moderate surgical risk and whose mitral valve (MV) has been determined to be suitable for correction by MV repair surgery by the cardiac surgeon on the local site heart team
Intervention
Mitraclip vs surgery
Location
TriStar Centennial
Sponsor
Abbott
Principal Investigator
Sreekumar Subramanian, MD
Research Coordinator
Sean O’Malley
Specialty
Structural
ClinicalTrials.gov
Condition
Heart Failure / Coronary Artery Disease
Intervention
Impella 5.5 support during CABG for patients with reduced EF
Location
TriStar Centennial
Sponsor
Abiomed
Principal Investigator
Seenu Reddy, MD
Research Coordinator
Abby Bentley
Specialty
Cardiothoracic Surgery
ClinicalTrials.gov
NCT: 05529654
Condition
High Risk Percutaneous Coronary Intervention
Intervention
Impella ECP assisted PCI
Location
TriStar Centennial
Sponsor
Abiomed
Principal Investigator
Brian Jefferson, MD
Research Coordinator
Drew Quillen
Specialty
Interventional Cardiology
ClinicalTrials.gov
NCT: 05334784
Condition
Left Atrial Appendage Closure
Intervention
Laminar vs Watchman for LAAC
Location
TriStar Centennial
Sponsor
J & J
Principal Investigator
Andrew Goodman, MD
Research Coordinator
Lauren Bozarth
Specialty
Interventional Cardiology
ClinicalTrials.gov
Study Details | Laminar LAAX Pivotal IDE Study | ClinicalTrials.gov
Condition
In-Stent Restenosis
Intervention
Agent DCB vs Prevail DCB
Location
TriStar Centennial
Sponsor
Medtronic
Principal Investigator
Brian Jefferson, MD
Research Coordinator
Anna Grace Sikes
Specialty
Interventional Cardiology
ClinicalTrials.gov
Condition
Native Valve Aortic Stenosis
Intervention
TAVR with the Sapien x4 valve
Location
TriStar Centennial
Sponsor
Edwards Lifesciences
Principal Investigator
Samuel Horr, MD
Research Coordinator
Hannah Vaughn
Specialty
Structural
ClinicalTrials.gov
NCT #: 05172960
Condition
Finerenone use in patients with HFpEF/MHmrEF
Intervention
Finerenone vs. Placebo
Location
TriStar Centennial
Sponsor
CPC Clinical Research
Principal Investigator
Zachary Il’Giovine MD
Research Coordinator
Sean O’Malley
Specialty
Heart Failure
ClinicalTrials.gov
NCT:06008197
Condition
Refractory Angina
Intervention
Coronary Sinus Reducer implant for refractory angina
Location
TriStar Centennial
Sponsor
Shockwave
Principal Investigator
Brian Jefferson MD
Research Coordinator
Drew Quillen
Specialty
Interventional
ClinicalTrials.gov
NCT: 05102019
Condition
Intermediate risk Pulmonary embolism
Intervention
Randomized 1:1- Heparin/AC versus Flowtriever
Location
TriStar Centennial
Sponsor
Inari/ Stryker
Principal Investigator
Samuel Horr MD
Research Coordinator
Lauren Bozarth
Specialty
Interventional
ClinicalTrials.gov
NCT: 0605592
Condition
High risk Pulmonary embolism
Intervention
Randomized 1:1- SOC versus Flowtriever
Location
TriStar Centennial
Sponsor
Inari/ Stryker
Principal Investigator
Samuel Horr MD
Research Coordinator
Lauren Bozarth
Specialty
Interventional
ClinicalTrials.gov
NCT: 06588634
Condition
Intermediate risk Pulmonary embolism
Intervention
Akura Thrombectomy system
Location
TriStar Centennial
Sponsor
Akura
Principal Investigator
Ann Gage MD
Research Coordinator
Lauren Bozarth
Specialty
Interventional
ClinicalTrials.gov
NCT: 06362928
Condition
Severe Tricuspid Regurgitation
Intervention
Trillium Implant
Location
TriStar Centennial
Sponsor
Innoventric
Principal Investigator
Sam Horr MD
Research Coordinator
Abby Bentley
Specialty
Structural
ClinicalTrials.gov
NCT: 06212193
Condition
Diabetes, Pre-Diabetes, Metabolic Syndrome
Intervention
Risk Factor Based Care vs Cleerly Coronary Artery Disease Staging System-based Care
Location
TriStar Centennial
Sponsor
Cleerly
Principal Investigator
David Huneycutt MD
Research Coordinator
Anna Morse
Specialty
Imaging
ClinicalTrials.gov
NCT: 06112418
Condition
Coronary Artery Disease
Intervention
A Randomized Comparison of Personalized Management for Medical and Interventional Therapy Based On Coronary Atherosclerotic Plaque Versus Usual Care for Symptomatic Patients with Suspicion of CAD
Location
TriStar Centennial
Sponsor
Cleerly
Principal Investigator
David Huneycutt MD
Research Coordinator
Anna Morse
Specialty
Imaging / Interventional
ClinicalTrials.gov
NCT: 06713239
Condition
Heart Failure
Intervention
Non-Invasive Venous Waveform Analysis with Pulmonary Capillary Wedge Pressure during cardiac catheterization.
Location
TriStar Centennial
Sponsor
Volumetrix
Principal Investigator
Ann Gage MD
Research Coordinator
Anna Morse
Specialty
Cardiac Disease
ClinicalTrials.gov
This is a pre-FDA approval observational study which will not be registered
Condition
De Novo lesions in Small Coronary Vessels
Intervention
PCI with Randomization to SELUTION DEB (sirolimus) or DES (limus-based stent)
Location
TriStar Centennial
Sponsor
MedAlliance LLC
Principal Investigator
Brian Jefferson, MD
Research Coordinator
Anna Grace Sikes, RN, BSN
Specialty
Interventional
ClinicalTrials.gov
NCT: 05946629
Condition
Coronary Calcified blockage
Intervention
Bolt Intravascular Lithotripsy
Location
TriStar Centennial
Sponsor
Bolt Medical
Principal Investigator
Brian Jefferson MD
Research Coordinator
Sean O’Malley
Specialty
Interventional
ClinicalTrials.gov
NCT: 06181240
Condition
Coronary artery disease
Intervention
CABG vs PCI in women and minorities
Location
TriStar Centennial
Sponsor
Weill Cornell Medicine
Principal Investigator
Brian Jefferson MD
Research Coordinator
Hannah Vaugh
Specialty
Surgical
ClinicalTrials.gov
NCT: 06399705
Condition
Calcified coronary artery disease
Intervention
Javelin Intravascular Lithotripsy
Location
TriStar Centennial
Sponsor
Shockwave
Principal Investigator
Brian Jefferson MD
Research Coordinator
Sean O’Malley
Specialty
Interventional
ClinicalTrials.gov
NCT: 06662500