Cardiac Clinical Trials
Centennial Heart is a proven leader in Cardiovascular Research. In 2007, Sarah Cannon Research Institute (SCRI) established our practice as a strategic investigative site for cardiovascular research in Nashville. Now, the program has expanded to 23 sites and is known as the HCA Healthcare Research Institute (HRI) specializing in: interventional cardiology, electrophysiology, cardiovascular disease, surgery and structural heart.
At Centennial Heart, our team pioneers clinical trials to constantly innovate solutions and improve patient outcomes.
We are proud to partner with SCRI in transforming cardiovascular therapies and advancing patient care. SCRI sets the standard for effectively managed, reliable clinical research trials.
National Leaders in Cardiac Research
Our nationally recognized cardiovascular research program is designed to provide state of the art, inventive approaches to clinical trial management. At Centennial Heart, our team pioneers clinical trials to constantly innovate solutions and improve patient outcomes.
Our physicians actively manage multiple studies with HCA Research Institute. Dr. Samuel Horr is the Clinical Director of Cardiovascular Research.
Condition
Coronary Artery Disease with severely calcified lesions
Intervention
PCI with orbital atherectomy versus conventional balloon angioplasty
Location
TriStar Centennial
Sponsor
Cardiovascular Systems, Inc.
Principal Investigator
Brian Jefferson, MD
Research Coordinator
Drew Quillen
Specialty
Interventional
ClinicalTrials.gov
ClinicalTrials.gov Identifier: NCT03108456
Condition
Chronic Total Occlusion
Intervention
PCI of the Chronic Total Occlusion
Location
TriStar Centennial
Sponsor
Minneapolis Heart Institute
Principal Investigator
Brian Jefferson, MD & Taral Patel, MD
Research Coordinator
Drew Quillen
Specialty
Interventional
ClinicalTrials.gov
ClinicalTrials.gov Identifier: NCT02061436
Condition
Symptomatic patients with severe tricuspid regurgitation
Intervention
Compare Abbott TriClip to control/medical therapy
Location
TriStar Centennial
Sponsor
Abbott
Principal Investigator
Samuel Horr, MD
Research Coordinator
Abdullah Shamsuddin
Specialty
Structural
Clinicaltrials.gov
ClinicalTrials.gov Identifier: NCT03904147Condition
Degenerative mitral regurgitation
Intervention
Compare the Edwards PASCAL System for transcatheter mitral valve repair to the Abbott MitraClip
Location
TriStar Centennial
Sponsor
Edwards
Principal Investigator
John Riddick, MD
Research Coordinator
Abdullah Shamsuddin
Specialty
Structural
ClinicalTrials.gov
ClinicalTrials.gov Identifier: NCT03706833
Condition
Heart Failure with functional mitral regurgitation
Intervention
Carillon implant versus control
Location
TriStar Centennial
Sponsor
Cardiac Dimensions
Principal Investigator
Andrew Goodman, MD
Research Coordinator
Abdullah Shamsuddin
Specialty
Structural
ClinicalTrials.gov
In start up
Condition
Moderate-to-severe or severe Mitral Regurgitation
Intervention
Tendyne mitral valve system versus MitraClip system
Location
TriStar Centennial
Sponsor
Abbott
Principal Investigator
Sreekumar Subramanian, MD
Research Coordinator
Brenda Merkelz
Specialty
Structural
ClinicalTrials.gov
ClinicalTrials.gov Identifier: NCT03433274
Condition
Uncontrolled Hypertension
Intervention
Renal denervation versus control
Location
TriStar Centennial
Sponsor
Medtronic
Principal Investigator
Brian Jefferson, MD
Research Coordinator
Molly Harper
Specialty
Interventional
ClinicalTrials.gov
ClinicalTrials.gov Identifier: NCT02439775
Condition
Aortic valve stenosis that is being treated with an approved TAVR device
Intervention
Sentinel Cerebral Protection System versus Control (no sentinel)
Location
TriStar Centennial
Sponsor
Boston Scientific
Principal Investigator
Samuel Horr, MD
Research Coordinator
Brenda Merkelz
Specialty
Structural
ClinicalTrials.gov
ClinicalTrials.gov Identifier: NCT04149535
Condition
Heart failure (HF) patients on maximum Guideline Directed Medical Therapy (GDMT) with elevated BNP labs or at least one HF hospitalization in last year
Intervention
V-wave interatrial shunt versus no V-wave shunt
Location
TriStar Centennial
Sponsor
V-Wave
Principal Investigator
A Thomas McRae III, MD
Research Coordinator
Drew Quillen
Specialty
Heart Failure
ClinicalTrials.gov
ClinicalTrials.gov Identifier: NCT03499236
Condition
Non-valvular Atrial Fibrillation (Afib)
Intervention
Watchman FLX versus Novel Oral Anticoagulants (NOACs)
Location
TriStar Centennial
Sponsor
Boston Scientific Corporation
Principal Investigator
Samuel Horr, MD
Research Coordinator
Molly Harper
Specialty
Electrophysiology
ClinicalTrials.gov
ClinicalTrials.gov Identifier: NCT04394546
Condition
Aortic Valve replacement with an On-x mechanical valve
Intervention
Eliquis (apixaban) versus standard of care (Coumadin/warfarin)
Location
TriStar Centennial
Sponsor
CryoLife
Principal Investigator
Seenu Reddy, MD
Research Coordinator
Molly Harper
Specialty
Structural
ClinicalTrials.gov
ClinicalTrials.gov Identifier: NCT04142658
Condition
Severe primary mitral regurgitation at moderate surgical risk and whose mitral valve (MV) has been determined to be suitable for correction by MV repair surgery by the cardiac surgeon on the local site heart team
Intervention
Mitraclip vs surgery
Location
TriStar Centennial
Sponsor
Abbott
Principal Investigator
Sreekumar Subramanian, MD
Research Coordinator
Brenda Merkelz
Specialty
Structural
ClinicalTrials.gov
Condition
Patients with small aortic annulus and symptomatic severe native aortic stenosis
Intervention
EVOLUT versus SAPIEN transcatheter aortic valve replacement devices
Location
TriStar Centennial
Sponsor
Medtronic
Principal Investigator
Andrew Goodman, MD
Research Coordinator
Abdullah Shamsuddin
Specialty
Structural
ClinicalTrials.gov
ClinicalTrials.gov Identifier: NCT04722250
Condition
Adults hospitalized with COVID-19
Intervention
Compare the effectiveness of antithrombotic strategies for prevention of adverse outcomes in COVID-19 positive inpatients
Location
TriStar Centennial
Sponsor
University of Pittsburg Medical Center, Matthew Neal, MD
Principal Investigator
Andrew Goodman, MD
Research Coordinator
Brenda Merkelz
Specialty
COVID
ClinicalTrials.gov
ClinicalTrials.gov Identifier: NCT04505774
Condition
ST Elevation (STEMI) Myocardial Infarction of Anterior Wall
Intervention
Impella CP placement prior to reperfusion with Primary PCI
Location
TriStar Centennial
Sponsor
Abiomed
Principal Investigator
Andrew Goodman, MD
Research Coordinator
Drew Quillen
Specialty
Interventional
ClinicalTrials.gov
ClinicalTrials.gov Identifier: NCT03947619
Condition
Patients with diabetes hospitalized with acute decompensated Heart Failure (ADHF)
Intervention
Dapagliflozin + Protocolized Diuretic Therapy versus Control (Protocolized Diuretic Therapy)
Location
TriStar Centennial
Sponsor
Vanderbilt University Medical Center
Principal Investigator
A Thomas McRae III, MD
Research Coordinator
Drew Quillen
Specialty
Heart Failure
ClinicalTrials.gov
ClinicalTrials.gov Identifier: NCT04298229
Condition
Heart attack (Myocardial Infarction)
Intervention
Empagliflozin versus placebo to see if it helps to lower the chances of having to go to the hospital for heart failure and whether it lowers the chances of dying from cardiovascular disease
Location
TriStar Centennial
Sponsor
Boehringer Ingelheim
Principal Investigator
Ann Gage, MD
Research Coordinators
Drew Quillen and Molly Harper
Specialty
Interventional
ClinicalTrials.gov
ClinicalTrials.gov Identifier: NCT04509674
Agent IDE
Condition
Patients with in-stent restenosis (ISR) of a previously treated lesion of up to 26 mm in length (by visual estimate) in a native coronary artery
Intervention
Agent DCB versus PTCA balloon catheter
Location
TriStar Centennial
Sponsor
Boston Scientific Corporation
Principal Investigator
Andrew Goodman, MD
Research Coordinator
Drew Quillen
Specialty
Interventional
ClinicalTrials.gov
ClinicalTrials.gov Identifier: NCT04647253
Condition
Coronary Artery Disease, Ischemic Heart Disease
Intervention
Comparing PCI guided by angiography versus iFR Co-Registration using commercially available Philips pressure guidewires and the SyncVision co-registration system, employing an adaptive design study for interim sample size re-estimation
Location
TriStar Centennial
Sponsor
Philips
Principal Investigator
Brian Jefferson, MD
Research Coordinator
Drew Quillen
Specialty
Interventional
ClinicalTrials.gov
ClinicalTrials.gov Identifier: NCT04451044
Enrolling by invitation
Condition
Acute decompensated heart failure
Intervention
Cardionomic cardiac pulmonary nerve stimulation therapy versus standard of care
Location
TriStar Centennial
Sponsor
Cardionomic Inc.
Principal Investigator
Ashley Bock, MD
Research Coordinator
Drew Quillen
Specialty
Interventional
ClinicalTrials.gov
ClinicalTrials.gov Identifier: NCT04814134
Condition
High-risk PCI in patients with reduced left-sided heart function
Intervention
Impella CP (or Impella 2.5) device compared to current standard of care
Location
TriStar Centennial
Sponsor
Abiomed Inc.
Principal Investigator
Andrew Goodman, MD
Research Coordinator
Drew Quillen
Specialty
Interventional
ClinicalTrials.gov
ClinicalTrials.gov Identifier: NCT04763200
In start up
Condition
Patients with severe degenerative mitral regurgitation (DMR)
Intervention
Harpoon beating heart mitral valve repair system
Location
TriStar Centennial
Sponsor
Edwards
Principal Investigator
Sreekumar Subramanian, MD
Research Coordinator
Brenda Merkelz
Specialty
Structural
ClinicalTrials.gov
ClinicalTrials.gov Identifier: NCT04375332