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Cardiac Clinical Trials

Centennial Heart is a proven leader in Cardiovascular Research. In 2007, Sarah Cannon Research Institute (SCRI) established our practice as a strategic investigative site for cardiovascular research in Nashville. Now, the program has expanded to 10 strategic sites and more than 125 cardiologists specializing in interventional cardiology, electrophysiology, cardiovascular disease, surgery and structural heart.

At Centennial Heart, our team pioneers clinical trials to constantly innovate solutions and improve patient outcomes.

We are proud to partner with SCRI in transforming cardiovascular therapies and advancing patient care. SCRI sets the standard for effectively managed, reliable clinical research trials.

National Leaders in Cardiac Research

Our nationally recognized cardiovascular research program is designed to provide state of the art, inventive approaches top clinical trial management. At Centennial Heart, our team pioneers clinical trials to constantly innovate solutions and improve patient outcomes.

All of our physicians actively manage multiple studies with SCRI and clinical physicians hold Directorships. Dr. Chris Jones is the Director of Electrophysiology Research. Dr. Jones' cardiac electrophysiology expertise includes evaluation of syncope and palpitations, medical management of arrhythmias, device implantation and follow-up, and catheter ablation of tachy-arrhythmias.

Current Clinical Trials

Condition

Device generator change or new CRT device needed

Intervention

Tyrex antibiotic envelope for generator versus none

Location
TriStar Centennial
Sponsor
Medtronic Inc.
Principal Investigator
R. Chris Jones, MD
Research Coordinator
Heather Spurlock, RN
Specialty
Electrophysiology

Condition

Heart failure with reduced EF, LBBB, biventricular dysynchrony

Intervention

CRT- D with Adapt mode randomized on or off

Location
TriStar Centennial
Sponsor
Medtronic Inc.
Principal Investigator
Peter Borek, MD
Research Coordinator
Heather Spurlock, RN
Specialty
Electrophysiology

Condition

Class IV angina post op CABG

Intervention

CABG

Location
TriStar Centennial
Sponsor
Cardiogenesis
Principal Investigator
Seenu Reddy, MD
Research Coordinator
Heather Spurlock, RN
Specialty
Cardiac Surgery

Condition

Congested Heart Failure

Intervention

Randomized to lung fluid monitoring Sensi Vest or standard of care

Location
TriStar Centennial
Sponsor
Sensible Medical
Principal Investigator
Thomas McRae, MD
Research Coordinator
Heather Spurlock, RN
Specialty
Cardiac Intervention

Condition

Coronary Artery Disease with a high bleeding risk

Intervention

Percutaneous Coronary Synergy Stent and 6 month DAPT therapy

Location
TriStar Centennial
Sponsor
Boston Scientific
Principal Investigator
Brian Jefferson, MD
Research Coordinator
Heather Spurlock, RN
Specialty
Cardiac Intervention

Condition

Extreme high risk Coronary Artery Disease in need of Left Ventricular support during PCI

Intervention

Percutaneous Coronary Intervention with randomization of PHP or Impella device

Location
TriStar Centennial
Sponsor
St. Jude Medical
Principal Investigator
Taral Patel, MD
Research Coordinator
Heather Spurlock, RN
Specialty
Cardiac Intervention

Condition

Congestive Heart Failure

Intervention

Implantation of FDA approved Pulmonary Artery Pressure device

Location
TriStar Centennial
Sponsor
St. Jude Medical
Principal Investigator
Thomas Johnston, MD
Research Coordinator
Heather Spurlock, RN
Specialty
Cardiac Intervention

Condition

Multivessel Coronary Artery Disease

Intervention

Randomization to Coronary Bypass Graft or Fractional Flow Rate guided PCI

Location
TriStar Centennial
Sponsor
St. Jude Medical/Medtronic Inc.
Principal Investigators
R. Paul Myers, MD & Seenu Reddy, MD
Research Coordinator
Heather Spurlock, RN
Specialty
Cardiac Intervention & Surgery

Condition

Severe Aortic Valve Stenosis

Intervention

Transcatheter Aortic Valve Replacement randomized to PORTICO valve or Commercial approved valve

Location
TriStar Centennial
Sponsor
St. Jude Medical
Principal Investigator
John Riddick, MD
Research Coordinator
Sharon Gates, RN
Specialty
Cardiac Intervention

Condition

Device generator change or new CRT device needed

Intervention

Use of Aggrastat (current dose or proposed dose) or Integrilin during PCI

Location
TriStar Centennial
Sponsor
Medicure
Principal Investigator
Brian Jefferson, MD
Research Coordinator
Sharon Gates, RN
Specialty
Cardiac Intervention